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Introduction: Histoplasmosis is caused by the dimorphic fungus Histoplasma capsulatum, whose clinical manifestations range from asymptomatic to disseminated and highly fatal disease. Objective: To present the case of a patient diagnosed with disseminated histoplasmosis and SARS-CoV-2 infection. Clinical case: The case of a 79-year-old man is presented with a history of systemic arterial hypertension and type 2 diabetes mellitus. He was admitted for a week with nonproductive cough, dyspnea, and fatigue on moderate exertion, and reported having a positive antigen test for SARS-CoV-2. During hospitalization, he presented clinical deterioration, needing mechanical ventilation due to respiratory infection associated with COVID-19. Despite this, he presented lymphadenopathy, hepatosplenomegaly, and umbilicated skin-colored papules suggestive of disseminated fungal infection. Suspecting co-infection, infection by Histoplasma capsulatum was confirmed by means of mini-bronchoalveolar lavage and antifungal treatment was initiated;however, the patient presented persistent clinical deterioration and died. Conclusion: Cases of co-infections with COVID-19 in patients without chronic diseases or immunosuppressive states are rare, their diagnosis being a challenge for medical personnel and requiring consideration of pulmonary fungal infections such as cryptococcosis or histoplasmosis in associated respiratory failure. to SARS-CoV-2 infection. © 2023, Editorial Ciencias Medicas. All rights reserved.
ABSTRACT
Background: In our experience during the first year of development of ACHOC-C19 study, we observed 26% mortality in patients with cancer and COVID 19 infection. The impact of vaccination was not evaluated prior to the implementation of this strategy worldwide in this kind of population. It was proposed to evaluate the effectiveness of immunization during the second phase of our investigation. Methods: Cohort study derived from the National Registry of Patients with Cancer and COVID-19 (ACHOCC-19). Data were collected from June 2021 since vaccine was available. Patients were: older than 18 years, diagnosed with cancer (solid tumors), treated and/or under follow-up, and with COVID-19 infection. The comparative analysis of the vaccinated and non-vaccinated cohort is presented. Outcomes included: all-cause mortality within 30 days of infection diagnosis, hospitalization, and mechanical ventilation. Effect estimation was performed through relative risk (RR) and multivariate analysis for each event, using generalized linear models of the binomial family. Results: 896 patients were included, 470 were older than 60 years (52.4%) and 59% women (n = 530). 172 patients were recruited in the vaccinated cohort and 724 in the non-vaccinated cohort (ratio: 1 to 4.2). The cumulative incidence of hospitalization among the unvaccinated was 42.4% (n = 307), and among the vaccinated, 29% (n = 50);invasive mechanical ventilation requirement was 8.4% (n = 61) in unvaccinated, and 4.6% (n = 8) in vaccinated. The cumulative incidence of mortality from all causes in the unvaccinated was 17% (n = 123) and in the vaccinated 4.65% (n = 8). Table summarizes the multivariate analysis. The adjusted RR for mortality for the unvaccinated is 3.4 (95% CI: 1.7-6.8), for hospitalization 1.36 (95% CI: 1.08-1.72), and for mechanical ventilation 2.1 (95% CI: 1.02-4.2). Conclusions: The incidence of complications and death in patients with cancer and COVID-19 infection is significantly higher in those who have not received a vaccination schedule compared to those who have been vaccinated. Immunization should be promoted and intensified in this population group.
ABSTRACT
In this study we try to observe, code and analyze the performance that different tactical systems offer to a professional soccer team. Through the observational method and the use of the SWOT analysis tool, the use of the game systems of the matches carried out before the covid19 (n = 25) of the 19-20 season is analyzed. Performance-related variables were analyzed taking into account the gaming system used and its context, in addition to performing a SWOT that would allow obtaining data on strategic factors of each system. The game systems were (1-4-2-2-2;1-3-1-4-2;1-3-4-3;1-3-4-1-2;1-4-2- 3-1). The 1-4-2-2 system was the most used (52%), it achieved more victories (57.14%), more draws (50%), most used as a visitor (46.15%) and at home (58.33%). The 3-defense game system prevailed when the rival used a striker (54.55%) and at the offensive level a system with two forwards was used 83% of times against a defense of 3. We can conclude that the analyzed team obtained a high performance After using a wide variety of game systems, obtaining advantages in competition that the SWOT tool helps us to collect in a simple, economical and efficient way. © 2021, Federacion Extremena de Balonmano, University of Extremadura. All rights reserved.
ABSTRACT
The trend in recent years of wanting to perfect strategies and tactical approaches has led football to evolve into new approaches that allow for much deeper and more rigorous strategic plans to be analyzed and developed. For this, methods such as the game model have been established, which aims to establish the key game patterns of a team in order to develop a structure that identifies and defines the characteristics of a team. The objective of this work is to carry out a case study that analyzes the game model of a professional soccer team in Germany by visualizing all its league games (n = 25) before COVID-19 and using a descriptive methodology, establishing 2 criteria and 4 elements of analysis. The results indicate, in general terms, that the team analyzed is a team marked by a combinative pattern of offensive play, which tries to unbalance the rival by progression through the central area of the field and which, at a defensive level, is defined as a team that tries to recover the ball as soon as possible, covering the interior corridors, being able to conclude how through a case study we can analyze and study the characteristics of a soccer team. © Copyright: Federación Española de Asociaciones de Docentes de Educación Física (FEADEF).